The in vivo assessment of an unusual new hemostat technology. Johnson, L.

7Johnson, L. (2008, April 24–27).

21st Annual Symposium on Advanced Wound Healing Society, San Diego, CA, United States.

Standardized laboratory studies have been used to show the effectiveness of OMNI-STAT and Celox as hemostats. The time taken to form a good clot using freshly drawn blood was assessed and recorded. OMNI-STAT significantly reduced the clotting time compared with the control tests (30.5 secs vs 816.5secs, respectively). The clots were removed from the test article and photographed after 20 minutes, OMNI-STAT showed a robust gel-like clot. (Johnson et al, 2008)

hemostat - Blood clots after 20 minutes

Blood clots after 20 minutes (Johnson et al, 2008)
Studies examining the hemostatic effect of the chitosan derived dressing on coagulation of anticoagulant treated blood showed that hemostasis is largely unaffected by the presence of anticoagulants. Whereas anticoagulant treated blood showed significant delays in coagulation in the standard laboratory tests, the presence of chitosan derived material led to coagulation times similar to those seen in the non anticoagulant treated blood. In this model the heparinised blood clotted in 48s and warfarinised blood in <30s when in contact with OMNI-STAT granules. (Johnson et al, 2008).

Time to clot blood - Omni-stat and colntrol

“OMNI-STAT has been shown to stop bleeding in as little as 30 seconds.” (Johnson et al, 2008)

time to clot heparinised blood

“OMNI-STAT has been proven effective even in the presence of anti-coagulants, such as: Heparin™, Coumadin™ (Warfarin).” (Johnson et al, 2008)

 
OMNI-STAT was able to clot freshly drawn heparinized blood that has been cooled to a temperature of 56°F. The mean clotting time for the OMNI-STAT treated blood was 20 seconds, whereas control blood failed to clot within the 10 minute test period (Data on File).

time to clot blood at reduced temperatures

OMNI-STAT on hypothermic blood

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